DaRe2THINK is a primary care clinical trial sponsored by the NIHR, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust. DaRe2THINK is a transformational project that will test a new way of running clinical trials at General Practices in the NHS. The trial will use health information already collected in the NHS to reduce the time taken for research, both for the patients and NHS staff. This will allow the NHS to reach new and larger groups of patients that could benefit from new treatments opening the possibility of research to populations that would not have previously taken part.